ProteinGym A
AI benchmark · Science
What is ProteinGym?
Protein fitness prediction benchmark comparing zero-shot models on DMS substitution assays with aggregate Spearman correlations and drill-downs by function, MSA depth, taxa, and mutation depth.
Tier A
Widely used: a lab reports it, or 50 or more models are scored on it.
How much stands behind a tier: usage, who backs it, a confirmed line from its own site or paper, and a clear read on X. High with three of the four, medium with two, low otherwise.
- 97 models scored
- in curated RL directories (1 pt)
On X · unclear, low buzz, from 1 post about ProteinGym in the last month
ProteinGym gets only passing mentions, such as alongside a genomic language model paper, with little direct discussion of its quality or standing.
How we got to tier A
- Adoption: 97 models scored. Tier A.
- On X: unclear, low buzz. “ProteinGym gets only passing mentions, such as alongside a genomic language model paper, with little direct discussion of its quality or standing.” No move.
- In curated RL directories: 1 point, a floor of none.
- Not yet confirmed by a line from its own site or paper.
A clear view on X moves a tier one step up or down; most entries don't move. How tiers work.
Not on the map yet: no line from its own site or paper places it in a domain.
Next: browse all benchmarks. Entry from the RL Research daily scrape of public sources, 2026-10-11 snapshot.