SPIKE-Bench B
AI benchmark
- Tier
- B why
- Snapshot
What is SPIKE-Bench?
SPIKE-Bench measures whether LLMs comply with toxin-design prompts and generate biologically plausible, predicted-toxic protein sequences, reported as a Functional Harmfulness Rate.
Health and bio mostly
“631 toxin-design prompts across seven functional categories, curated from manually reviewed UniProtKB/Swiss-Prot toxin entries.”
github.com/PKU-Alignment/SPIKE-Bench ↗
Paper: arxiv.org/abs/2608.02684v2 ↗
Tier B
Established: 15 or more models scored, or curated RL directories rate it.
How much stands behind a tier: usage, who backs it, a confirmed line from its own site or paper, and a clear read on X. High with three of the four, medium with two, low otherwise.
- 27 models scored
- in curated RL directories (1 pt)
How we got to tier B
- Adoption: 27 models scored. Tier B.
- On X: unclear, none buzz No move.
- In curated RL directories: 1 point, a floor of none.
- Confirmed: a line from its own site or paper places it.
A clear view on X moves a tier one step up or down; most entries don't move. How tiers work.
Where SPIKE-Bench sits
Its domain on the map, live. Hover a logo for its name; click to open it. Open it on the full map
Next: browse all benchmarks. Entry from the RL Research daily scrape of public sources, 2026-10-19 snapshot.